Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 i...

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Main Authors: Manjeera Gowravaram, Juliane Schwarz, Sana K. Khilji, Henning Urlaub, Sutapa Chakrabarti
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13080-x
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spelling doaj-254321cfddc94877a3603f84eb782f0d2021-05-11T11:53:05ZengNature Publishing GroupNature Communications2041-17232019-11-0110111410.1038/s41467-019-13080-xInsights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNPManjeera Gowravaram0Juliane Schwarz1Sana K. Khilji2Henning Urlaub3Sutapa Chakrabarti4Institute of Chemistry and Biochemistry, Freie Universität BerlinBioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical ChemistryInstitute of Chemistry and Biochemistry, Freie Universität BerlinBioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical ChemistryInstitute of Chemistry and Biochemistry, Freie Universität BerlinThe Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 in Staufen-mediated mRNA decay.https://doi.org/10.1038/s41467-019-13080-x
collection DOAJ
language English
format Article
sources DOAJ
author Manjeera Gowravaram
Juliane Schwarz
Sana K. Khilji
Henning Urlaub
Sutapa Chakrabarti
spellingShingle Manjeera Gowravaram
Juliane Schwarz
Sana K. Khilji
Henning Urlaub
Sutapa Chakrabarti
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
Nature Communications
author_facet Manjeera Gowravaram
Juliane Schwarz
Sana K. Khilji
Henning Urlaub
Sutapa Chakrabarti
author_sort Manjeera Gowravaram
title Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_short Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_full Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_fullStr Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_full_unstemmed Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_sort insights into the assembly and architecture of a staufen-mediated mrna decay (smd)-competent mrnp
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 in Staufen-mediated mRNA decay.
url https://doi.org/10.1038/s41467-019-13080-x
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AT sanakkhilji insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp
AT henningurlaub insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp
AT sutapachakrabarti insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp
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