Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-m...

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Main Authors:	Yonatan R. Lewis-Israeli, Aaron H. Wasserman, Mitchell A. Gabalski, Brett D. Volmert, Yixuan Ming, Kristen A. Ball, Weiyang Yang, Jinyun Zou, Guangming Ni, Natalia Pajares, Xanthippi Chatzistavrou, Wen Li, Chao Zhou, Aitor Aguirre
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25329-5

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spelling	doaj-253ca09085994e7ca7cf500eaaf085e02021-08-29T11:38:31ZengNature Publishing GroupNature Communications2041-17232021-08-0112111610.1038/s41467-021-25329-5Self-assembling human heart organoids for the modeling of cardiac development and congenital heart diseaseYonatan R. Lewis-Israeli0Aaron H. Wasserman1Mitchell A. Gabalski2Brett D. Volmert3Yixuan Ming4Kristen A. Ball5Weiyang Yang6Jinyun Zou7Guangming Ni8Natalia Pajares9Xanthippi Chatzistavrou10Wen Li11Chao Zhou12Aitor Aguirre13Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDivision of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDivision of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDivision of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDepartment of Biomedical Engineering, Washington University in Saint LouisDivision of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDivision of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDepartment of Biomedical Engineering, Washington University in Saint LouisDepartment of Biomedical Engineering, Washington University in Saint LouisDepartment of Chemical Engineering and Material Science, College of Engineering, Michigan State UniversityDepartment of Chemical Engineering and Material Science, College of Engineering, Michigan State UniversityDivision of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State UniversityDepartment of Biomedical Engineering, Washington University in Saint LouisDivision of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State UniversityThere is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-matched fetal cardiac tissues and recreate a model of pregestational diabetes.https://doi.org/10.1038/s41467-021-25329-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yonatan R. Lewis-Israeli Aaron H. Wasserman Mitchell A. Gabalski Brett D. Volmert Yixuan Ming Kristen A. Ball Weiyang Yang Jinyun Zou Guangming Ni Natalia Pajares Xanthippi Chatzistavrou Wen Li Chao Zhou Aitor Aguirre
spellingShingle	Yonatan R. Lewis-Israeli Aaron H. Wasserman Mitchell A. Gabalski Brett D. Volmert Yixuan Ming Kristen A. Ball Weiyang Yang Jinyun Zou Guangming Ni Natalia Pajares Xanthippi Chatzistavrou Wen Li Chao Zhou Aitor Aguirre Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease Nature Communications
author_facet	Yonatan R. Lewis-Israeli Aaron H. Wasserman Mitchell A. Gabalski Brett D. Volmert Yixuan Ming Kristen A. Ball Weiyang Yang Jinyun Zou Guangming Ni Natalia Pajares Xanthippi Chatzistavrou Wen Li Chao Zhou Aitor Aguirre
author_sort	Yonatan R. Lewis-Israeli
title	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_short	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_full	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_fullStr	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_full_unstemmed	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_sort	self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-matched fetal cardiac tissues and recreate a model of pregestational diabetes.
url	https://doi.org/10.1038/s41467-021-25329-5
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Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

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