Ubiquitin Modification Patterns of Clear Cell Renal Cell Carcinoma and the Ubiquitin Score to Aid Immunotherapy and Targeted Therapy

Ubiquitin Modification Patterns of Clear Cell Renal Cell Carcinoma and the Ubiquitin Score to Aid Immunotherapy and Targeted Therapy

Ubiquitin modification is the most common protein post-translational modification (PTM) process in organisms, and 1332 ubiquitin regulators have been identified in humans. Ubiquitin regulators, especially E3 ligases and deubiquitinases, are widely involved in immune processes. This study aims to exp...

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Bibliographic Details
Main Authors: Peng Zhou, Yuchao Lu, Yang Xun, Jinzhou Xu, Chenqian Liu, Qidong Xia, Junlin Lu, Shaogang Wang, Jia Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ubiquitin code
unsupervised consensus clustering
clear-cell renal-cell carcinoma
immune signature
immune checkpoint blockade
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.659294/full

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