Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of loc...

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Main Authors: Mu Yang, Jian-Xin Dong, Lu-Bin Li, Hai-Jie Che, Jun Yong, Fu-Bo Song, Tao Wang, Jv-Wen Zhang
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2016/2604032
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spelling doaj-2537a3a7484640648963fc81d076adcf2020-11-24T21:24:00ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/26040322604032Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion ModelMu Yang0Jian-Xin Dong1Lu-Bin Li2Hai-Jie Che3Jun Yong4Fu-Bo Song5Tao Wang6Jv-Wen Zhang7Department of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, ChinaIntestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis.http://dx.doi.org/10.1155/2016/2604032
collection DOAJ
language English
format Article
sources DOAJ
author Mu Yang
Jian-Xin Dong
Lu-Bin Li
Hai-Jie Che
Jun Yong
Fu-Bo Song
Tao Wang
Jv-Wen Zhang
spellingShingle Mu Yang
Jian-Xin Dong
Lu-Bin Li
Hai-Jie Che
Jun Yong
Fu-Bo Song
Tao Wang
Jv-Wen Zhang
Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
Gastroenterology Research and Practice
author_facet Mu Yang
Jian-Xin Dong
Lu-Bin Li
Hai-Jie Che
Jun Yong
Fu-Bo Song
Tao Wang
Jv-Wen Zhang
author_sort Mu Yang
title Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_short Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_full Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_fullStr Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_full_unstemmed Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_sort local and remote postconditioning decrease intestinal injury in a rabbit ischemia/reperfusion model
publisher Hindawi Limited
series Gastroenterology Research and Practice
issn 1687-6121
1687-630X
publishDate 2016-01-01
description Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis.
url http://dx.doi.org/10.1155/2016/2604032
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