Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates

We report the synthesis and characterisation of a novel series of triazole benzenesulfonamide derivatives, which incorporate the general pharmacophore associated with carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The synthesised compounds were tested in vitro against four human carbonic anhydrase...

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Bibliographic Details
Main Authors: Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Online Access:http://dx.doi.org/10.1080/14756366.2018.1513927