HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension

HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension

The impact of high-density lipoprotein (HDL) cholesterol on the development of atherosclerosis and diseases of systemic circulation has been well documented both in experimental and registry studies. Recent discoveries in pulmonary arterial hypertension (PAH) revealed a significant impact of HDL on...

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Main Authors: Kamil Jonas, Grzegorz Kopeć
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
lipoprotein metabolism
inflammation
endothelium
microRNA
Online Access:https://www.mdpi.com/1422-0067/20/14/3514
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spelling doaj-2530436198054cc7a7f759ef4c9e7ee42020-11-25T01:45:41ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-07-012014351410.3390/ijms20143514ijms20143514HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial HypertensionKamil Jonas0Grzegorz Kopeć1Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, 31-202 Krakow, PolandDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, 31-202 Krakow, PolandThe impact of high-density lipoprotein (HDL) cholesterol on the development of atherosclerosis and diseases of systemic circulation has been well documented both in experimental and registry studies. Recent discoveries in pulmonary arterial hypertension (PAH) revealed a significant impact of HDL on pulmonary artery vasoreactivity and patients’ prognosis. The vasoprotective activity of HDL primarily involves vascular endothelium that also plays a central role in pulmonary arterial hypertension (PAH) pathobiology. However, the exact mechanism in which this lipoprotein fraction exerts its effect in pulmonary circulation is still under investigation. This paper reviews potential vasoprotective mechanisms of HDL in pulmonary circulation and presents current clinical reports on the role of HDL in PAH patients.https://www.mdpi.com/1422-0067/20/14/3514lipoprotein metabolisminflammationendotheliummicroRNA
collection DOAJ
language English
format Article
sources DOAJ
author Kamil Jonas
Grzegorz Kopeć
spellingShingle Kamil Jonas
Grzegorz Kopeć
HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
International Journal of Molecular Sciences
lipoprotein metabolism
inflammation
endothelium
microRNA
author_facet Kamil Jonas
Grzegorz Kopeć
author_sort Kamil Jonas
title HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
title_short HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
title_full HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
title_fullStr HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
title_full_unstemmed HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
title_sort hdl cholesterol as a marker of disease severity and prognosis in patients with pulmonary arterial hypertension
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-07-01
description The impact of high-density lipoprotein (HDL) cholesterol on the development of atherosclerosis and diseases of systemic circulation has been well documented both in experimental and registry studies. Recent discoveries in pulmonary arterial hypertension (PAH) revealed a significant impact of HDL on pulmonary artery vasoreactivity and patients’ prognosis. The vasoprotective activity of HDL primarily involves vascular endothelium that also plays a central role in pulmonary arterial hypertension (PAH) pathobiology. However, the exact mechanism in which this lipoprotein fraction exerts its effect in pulmonary circulation is still under investigation. This paper reviews potential vasoprotective mechanisms of HDL in pulmonary circulation and presents current clinical reports on the role of HDL in PAH patients.
topic lipoprotein metabolism
inflammation
endothelium
microRNA
url https://www.mdpi.com/1422-0067/20/14/3514
work_keys_str_mv AT kamiljonas hdlcholesterolasamarkerofdiseaseseverityandprognosisinpatientswithpulmonaryarterialhypertension
AT grzegorzkopec hdlcholesterolasamarkerofdiseaseseverityandprognosisinpatientswithpulmonaryarterialhypertension
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