IL-2 and Anti-TGF-β Promote NK Cell Reconstitution and Anti-tumor Effects after Syngeneic Hematopoietic Stem Cell Transplantation

IL-2 and Anti-TGF-β Promote NK Cell Reconstitution and Anti-tumor Effects after Syngeneic Hematopoietic Stem Cell Transplantation

The failure of autologous hematopoietic stem cell transplantation (HSCT) has been associated with a profound immunodeficiency that follows shortly after treatment, which renders patients susceptible to opportunistic infections and/or cancer relapse. Thus, given the additional immunosuppressive pathw...

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Bibliographic Details
Main Authors: Maite Alvarez, Cordelia Dunai, Lam T. Khuat, Ethan G. Aguilar, Isabel Barao, William J. Murphy
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
HSCT
IL-2
TGF-β
NK cells
myeloid cells
immune reconstitution
Online Access:https://www.mdpi.com/2072-6694/12/11/3189

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