A facile synthesis of new 5-aryl-thiophenes bearing sulfonamide moiety via Pd(0)-catalyzed Suzuki–Miyaura cross coupling reactions and 5-bromothiophene-2-acetamide: As potent urease inhibitor, antibacterial agent and hemolytically active compounds

A facile synthesis of new 5-aryl-thiophenes bearing sulfonamide moiety via Pd(0)-catalyzed Suzuki–Miyaura cross coupling reactions and 5-bromothiophene-2-acetamide: As potent urease inhibitor, antibacterial agent and hemolytically active compounds

The present study reports a convenient approach for the synthesis of thiophene sulfonamide derivatives (3a–3k) via Suzuki cross coupling reaction. This method of synthesis involved the reactions of various aryl boronic acids and esters with 5-bromthiophene-2-sulfonamide (2) under mild and suitable t...

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Bibliographic Details
Main Authors: Mnaza Noreen, Nasir Rasool, Yasmeen Gull, Faiz-ul-Hassan Nasim, Ameer Fawad Zahoor, Asma Yaqoob, Shazia Kousar, Muhammad Zubair, Iftikhar Hussain Bukhari, Usman Ali Rana
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Saudi Chemical Society
Subjects:
Thiophene sulfonamides
Palladium
Suzuki cross coupling
Catalysis
Antibacterial activity
Urease inhibition activity
Hemolytic activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610314000635

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http://www.sciencedirect.com/science/article/pii/S1319610314000635

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