Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors

Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors

Macrophages play a key role in atherogenesis in part through excessive uptake of oxidized LDL (OxLDL) via scavenger receptors. Binding of OxLDL to macrophages has traditionally been assessed using radiolabeled OxLDL. To allow more efficient and convenient measurements, we developed a nonradioactive...

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Bibliographic Details
Main Authors: Erica N. Montano, Agnès Boullier, Felicidad Almazan, Christoph J. Binder, Joseph L. Witztum, Karsten Hartvigsen
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
macrophages
oxidized LDL
CD36
SR-A
monoclonal antibody E06
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350720

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