Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs

Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs

Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome, and autism. Identification of the molecular targe...

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Bibliographic Details
Main Authors: Shanshan Wang, Zheng Zhang, Angels Almenar-Queralt, Joseph Leem, Celine DerMardirossian, David M. Roth, Piyush M. Patel, Hemal H. Patel, Brian P. Head
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NPCs
iPSCs
caveolin-1
phosphorylation
Rac1/Cdc42
axonal growth
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00324/full

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