Mechanistic studies of antibody mediated clearance of tau aggregates using an ex vivo brain slice model

Mechanistic studies of antibody mediated clearance of tau aggregates using an ex vivo brain slice model

Recent studies have shown that immunotherapy clears amyloid beta (A) plaques and reduces A levels in mouse models of Alzheimer’s disease (AD), as well as in AD patients. Tangle pathology is also relevant for the neurodegeneration in AD, and our studies have shown that active immunization with an A...

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Bibliographic Details
Main Authors: Pavan eKrishnamurthy, Yan eDeng, Einar M Sigurdsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Frontiers in Psychiatry
Subjects:
Antibodies
Endosomes
Immunotherapy
Lysosomes
tau
slice culture
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2011.00059/full

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