Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD

Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD

It has been reported that angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the main cell entry proteins for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and play a critical role in causing coronavirus disease 2019 (COVID-19). To investigate the...

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Bibliographic Details
Main Authors: Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Mashael Alabed, Mohamed-Hani Temsah, Saba Al Heialy, Qutayba Hamid, Rabih Halwani
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
ACE2
TMPRSS2
SARS-CoV-2
COVID-19
nasal epithelium
COPD
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301005

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