MAF1 represses CDKN1A through a Pol III-dependent mechanism

MAF1 represses CDKN1A through a Pol III-dependent mechanism

MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment. Simultaneous knockdown of MAF1 with Pol III or BRF1 (subunit of TFIIIB) diminished the...

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Bibliographic Details
Main Authors: Yu-Ling Lee, Yuan-Ching Li, Chia-Hsin Su, Chun-Hui Chiao, I-Hsuan Lin, Ming-Ta Hsu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
MAF1
Pol III
CDKN1A
Online Access:https://elifesciences.org/articles/06283

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