Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.

Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.

Plasma uric acid (UA) levels decrease following clinical progression and stage development of Parkinson's disease (PD). However, the molecular mechanisms underlying decreases in plasma UA levels remain unclear, and the potential to apply mutagenesis to a PD model has not previously been discove...

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Main Authors: Hiroko Tabunoki, Hiromasa Ono, Hiroaki Ode, Kazuhiro Ishikawa, Natsuki Kawana, Yutaka Banno, Toru Shimada, Yuki Nakamura, Kimiko Yamamoto, Jun-Ichi Satoh, Hidemasa Bono
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23894418/pdf/?tool=EBI

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