Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors

Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors

<p>Abstract</p> <p>Background</p> <p>The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-ligation. Attempts at new...

Full description

Bibliographic Details
Main Authors: Chen Chiao-En, Wu Jui-Yu, Lai Zhi-Yang, Lin Li-Wei, Tsai Hsiang-Ping, Hwang Jaulang, Chen Chien-Shu, Lin Chun-Mao
Format: Article
Language:English
Published: BMC 2010-06-01
Series:Journal of Biomedical Science
Online Access:http://www.jbiomedsci.com/content/17/1/49

Similar Items

Similar Items