TKI-Resistant Renal Cancer Secretes Low-Level Exosomal miR-549a to Induce Vascular Permeability and Angiogenesis to Promote Tumor Metastasis

TKI-Resistant Renal Cancer Secretes Low-Level Exosomal miR-549a to Induce Vascular Permeability and Angiogenesis to Promote Tumor Metastasis

Tyrosine kinase inhibitors (TKI)-resistant renal cancer is highly susceptible to metastasis, and enhanced vascular permeability promotes the process of metastasis. To evaluate the effect of cancer-derived exosomes on vascular endothelial cells and clarify the mechanism of metastasis in TKI-resistant...

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Bibliographic Details
Main Authors: Zuodong Xuan, Chen Chen, Wenbin Tang, Shaopei Ye, Jianzhong Zheng, Yue Zhao, Zhiyuan Shi, Lei Zhang, Huimin Sun, Chen Shao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TKI-resistant
clear cell renal cell carcinoma
exosome
microRNA
HIF1α
vascular endothelial permeability
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.689947/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.689947/full

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