Activation of Neuregulin 1/ErbB Signaling Is Involved in the Development of TOCP-Induced Delayed Neuropathy

Activation of Neuregulin 1/ErbB Signaling Is Involved in the Development of TOCP-Induced Delayed Neuropathy

Organophosphate-induced delayed neuropathy (OPIDN) is characterized by progressive axonal degeneration and demyelination of the spinal cord and sciatic nerves. The neuregulin 1/epidermal growth factor receptor (ErbB) signaling pathway is crucial for axonal myelination. In this study, we investigated...

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Bibliographic Details
Main Authors: Hai-Yang Xu, Pan Wang, Ying-Jian Sun, Ming-Yuan Xu, Li Zhu, Yi-Jun Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
organophosphate-induced delayed neuropathy
hen
neuregulin 1
ErbB
lapatinib
neuropathy target esterase
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00129/full

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