Assessment of Oxidative Stress in Recipients of Chronic Transfusion Therapy

• Main Authors: Jayanta De, Kaushik Bhowmick, Utpal Chowdhury, Gopaldev Chattopadhyay, Indranil Chakraborty
• Format: Article
• Language: English
• Published: Gomal Medical College, D.I.Khan, Pakistan 2013-07-01
• Series: Gomal Journal of Medical Sciences
• Subjects: oxidative stress; transfusion therapy; reduced glutathione; vitamin e; malondialdehyde; ferritin
• Online Access: http://gjms.com.pk/ojs24/index.php/gjms/article/view/502

Background: Excess iron deposition in chronically transfused patients may cause organ damage through generation of free radicals and resultant oxidative stress. The objective of study was to assess the oxidative stress in recipients of chronic transfusion therapy. Material and Methods: This cross-sectional study was undertaken in Department of Biochemistry, Medical College & Hospital, Kolkata, India in collaboration with Institute of Hematology & Transfusion Medicine of the same institute from May, 2007 to April, 2008. Serum Malondialdehyde, Vitamin E, erythrocyte reduced glutathione, osmotic fragility of red blood cells and serum ferritin were measured. Results: Serum malondialdehyde concentration in cases 7.87+1.44nmol/ml was significantly higher than that of controls 5.00+1.27nmol/ml (p