The neurotoxin 1-methyl-4-phenylpyridinium (MPP+) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system

The neurotoxin 1-methyl-4-phenylpyridinium (MPP+) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system

The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces Parkinson’s disease (PD)-like symptoms following administration to mice, monkeys and humans. A common view is that MPTP is metabolized to 1-methyl-4-phenylpyridinium ion (MPP+) to induce its neurodegenerative effects on dopam...

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Bibliographic Details
Main Authors: YuYing eHuang, JunFang eChen, Ying eChen, YingHan eZhuang, Mu eSun, Thomas eBehnisch
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Limbic System
dopaminergic system
tonic inhibition
synaptic transmission;
Parkinson’s disease (PD)
Extrasynaptic GABAergic receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00299/full

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