CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression

CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression

Ming Ji,1 Liyuan Wang,1 Ju Chen,1 Nina Xue,2 Chunyang Wang,2 Fangfang Lai,2 Rubing Wang,1 Shishan Yu,1 Jing Jin,1,2 Xiaoguang Chen1,2 1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union M...

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Bibliographic Details
Main Authors: Ji M, Wang L, Chen J, Xue N, Wang C, Lai F, Wang R, Yu SS, Jin J, Chen X
Format: Article
Language:English
Published: Dove Medical Press 2018-06-01
Series:OncoTargets and Therapy
Subjects:
Glioblastoma
Hedgehog
MGMT
TMZ
Gli inhibitor
Online Access:https://www.dovepress.com/cat3-a-prodrug-of-13as-3-hydroxyl-67-dimethoxyphenanthro910-b-indolizi-peer-reviewed-article-OTT

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