Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of dyskinetic behaviors. Thus far, validated rating scale...

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Bibliographic Details
Main Authors: Irene Sebastianutto, Natallia Maslava, Corey R. Hopkins, M. Angela Cenci
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Movement disorders
Dystonia
Rodent models
Experimental therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302170

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