Functional status of liverin conditions of radiation and chemical exposure

• Main Authors: O. V. Severynovs’ka, Т. М. Lagutina, О. Y. Zaichenko, A. I. Dvoretskyi
• Format: Article
• Language: English
• Published: Oles Honchar Dnipropetrovsk National University 2005-09-01
• Series: Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ
• Online Access: http://ecology.dp.ua/index.php/ECO/article/view/582
• ISSN: 2310-0842; 2312-301X

Chronic influences of low-intensity X-rays in doses of 0.15 and 0.25 Gr and mix of heavy metals salts in a dose of 2 EPC (extreme permissible concentrations) for each metal, as a single factor or as a combination of factors, on the state of pro-/antioxidative system in a rat liver have been studied. Analysis of the data concerning combined influences allows to conclude that effects under these doses have some differences: a splash of processes of lipid peroxidation are observed in both causes, but under the lower dose an additivity takes place, and under the dose of 0.25 Gr a synergism of the agent effects in relation to the development of peroxidative reactions is registered. The results testify that technogenic contamination of water with heavy metals worsens the action of radiation factor, specifically, eliminates a hormetic splash of antioxidative activity at 0.15 Gr. Biochemical indexes of the liver activity, as a central organ of a general metabolism, and a structure of morbidity have been studied in liquidators of the Chernobyl accident from industrial Prydnieprovie region. Disturbances of liver functions have been shown, especially in persons obtained the exposure dose about 0.25 Gr. A comparison of these results and data of tests with laboratory animals reveals their mutual accordance and supports a relevancy of extrapolation of data of model experiments on a person health state, which undergone a similar influence.