Ultra-Mutation in <i>IDH</i> Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment

Ultra-Mutation in <i>IDH</i> Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment

Background: Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (<i>IDH)</i> mutants and <i>IDH</i> wild-types (<i>IDH</i>-wt). This study aimed at identifying the mutational assets of <i>IDH</i>-wt GBMs in patients aged 18&#8722;54 y...

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Bibliographic Details
Main Authors: Valeria Barresi, Michele Simbolo, Andrea Mafficini, Maria Liliana Piredda, Maria Caffo, Salvatore Massimiliano Cardali, Antonino Germanò, Sara Cingarlini, Claudio Ghimenton, Aldo Scarpa
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
glioblastoma
<i>IDH</i> wild-type
giant cells
mismatch repair
<i>POLE</i>
tumour mutation load
Online Access:https://www.mdpi.com/2072-6694/11/9/1279

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https://www.mdpi.com/2072-6694/11/9/1279

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