Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

• Main Authors: Pierluigi Caboni, Filippo Cottiglia, Carlos A. Bueno, Marco Leonti, Simona Vargiu, Urania Menkissoglu-Spiroudi, Ersilia Bifulco, Laura E. Alché, Nikoletta G. Ntalli
• Format: Article
• Language: English
• Published: MDPI AG 2010-08-01
• Series: Molecules
• Subjects: methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity
• Online Access: http://www.mdpi.com/1420-3049/15/9/5866/
• ISSN: 1420-3049

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.