Castleman's Disease: A Study of a Rare Lymphoproliferative Disorder in a University Hospital

• Main Authors: Ibrahiem Saeed Abdul-Rahman, Ali M. Al-Amri, Khalid Qassim Ghallab
• Format: Article
• Language: English
• Published: SAGE Publishing 2009-01-01
• Series: Clinical Medicine Insights: Blood Disorders
• Online Access: https://doi.org/10.4137/CMBD.S2161

Castleman's disease (CD) is a group of rare lymphoproliferative disorders sharing characteristic clinical and histological features, and usually accompanied by a marked systemic inflammatory response. Three histological patterns of lymph nodes were described: the hyaline-vascular, the plasma-cell and the mixed types. The former is more common (80%-90%) and tends to be localized. The plasma cell type is more aggressive and usually multicentric. It is interesting that the inflammatory manifestations seem to be related to a lymph node lesion, because the systemic symptoms and inflammatory activity can return to normal after surgical excision or successful medical treatment of the disease. We report here our 15-year experience with this rare disease in King Fahd Hospital of the University, Al-Khobar, Saudi Arabia , focusing on the clinical features, therapy, and patients'outcome.