Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma

Objectives. The aim of this study is to explore the textural features that may identify the morphological changes in the lymphoma region and predict the prognosis of patients with primary renal lymphoma (PRL) and primary adrenal lymphoma (PAL). Methods. This retrospective study comprised nineteen no...

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Main Authors: Manni Wang, Hui Xu, Liu Xiao, Wenpeng Song, Sha Zhu, Xuelei Ma
Format: Article
Language:English
Published: Hindawi-Wiley 2019-01-01
Series:Contrast Media & Molecular Imaging
Online Access:http://dx.doi.org/10.1155/2019/2641627
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spelling doaj-248be918ef9b4403a910985aac39e89e2020-11-25T00:29:46ZengHindawi-WileyContrast Media & Molecular Imaging1555-43091555-43172019-01-01201910.1155/2019/26416272641627Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal LymphomaManni Wang0Hui Xu1Liu Xiao2Wenpeng Song3Sha Zhu4Xuelei Ma5Department of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Radiology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaObjectives. The aim of this study is to explore the textural features that may identify the morphological changes in the lymphoma region and predict the prognosis of patients with primary renal lymphoma (PRL) and primary adrenal lymphoma (PAL). Methods. This retrospective study comprised nineteen non-Hodgkin’s lymphoma (NHL) patients undergoing 18F-FDG-PET/CT at West China Hospital from December 2013 to May 2017. 18F-FDG-PET images were reviewed independently by two board certificated radiologists of nuclear medicine, and the texture features were extracted from LifeX packages. The prognostic value of PET FDG-uptake parameters, patients’ baseline characteristics, and textural parameters were analyzed using Kaplan–Meier analysis. Cox regression analysis was used to identify the independent prognostic factors among the imaging and clinical features. Results. The overall survival of included patients was 18.84 ± 13.40 (mean ± SD) months. Univariate Cox analyses found that the tumor stage, GLCM (gray-level co-occurrence matrix) entropy, GLZLM_GLNU (gray-level nonuniformity), and GLZLM_ZLNU (zone length nonuniformity), values were significant predictors for OS. Among them, GLRLM_RLNU ≥216.6 demonstrated association with worse OS at multivariate analysis (HR 9.016, 95% CI 1.041–78.112, p=0.046). Conclusions. The texture analysis of 18F-FDG-PET images could potentially serve as a noninvasive strategy to predict the overall survival of patients with PRL and PAL.http://dx.doi.org/10.1155/2019/2641627
collection DOAJ
language English
format Article
sources DOAJ
author Manni Wang
Hui Xu
Liu Xiao
Wenpeng Song
Sha Zhu
Xuelei Ma
spellingShingle Manni Wang
Hui Xu
Liu Xiao
Wenpeng Song
Sha Zhu
Xuelei Ma
Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma
Contrast Media & Molecular Imaging
author_facet Manni Wang
Hui Xu
Liu Xiao
Wenpeng Song
Sha Zhu
Xuelei Ma
author_sort Manni Wang
title Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma
title_short Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma
title_full Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma
title_fullStr Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma
title_full_unstemmed Prognostic Value of Functional Parameters of 18F-FDG-PET Images in Patients with Primary Renal/Adrenal Lymphoma
title_sort prognostic value of functional parameters of 18f-fdg-pet images in patients with primary renal/adrenal lymphoma
publisher Hindawi-Wiley
series Contrast Media & Molecular Imaging
issn 1555-4309
1555-4317
publishDate 2019-01-01
description Objectives. The aim of this study is to explore the textural features that may identify the morphological changes in the lymphoma region and predict the prognosis of patients with primary renal lymphoma (PRL) and primary adrenal lymphoma (PAL). Methods. This retrospective study comprised nineteen non-Hodgkin’s lymphoma (NHL) patients undergoing 18F-FDG-PET/CT at West China Hospital from December 2013 to May 2017. 18F-FDG-PET images were reviewed independently by two board certificated radiologists of nuclear medicine, and the texture features were extracted from LifeX packages. The prognostic value of PET FDG-uptake parameters, patients’ baseline characteristics, and textural parameters were analyzed using Kaplan–Meier analysis. Cox regression analysis was used to identify the independent prognostic factors among the imaging and clinical features. Results. The overall survival of included patients was 18.84 ± 13.40 (mean ± SD) months. Univariate Cox analyses found that the tumor stage, GLCM (gray-level co-occurrence matrix) entropy, GLZLM_GLNU (gray-level nonuniformity), and GLZLM_ZLNU (zone length nonuniformity), values were significant predictors for OS. Among them, GLRLM_RLNU ≥216.6 demonstrated association with worse OS at multivariate analysis (HR 9.016, 95% CI 1.041–78.112, p=0.046). Conclusions. The texture analysis of 18F-FDG-PET images could potentially serve as a noninvasive strategy to predict the overall survival of patients with PRL and PAL.
url http://dx.doi.org/10.1155/2019/2641627
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