Cytotoxic Sesquiterpenoids from the Stem Bark of <i>Aglaia harmsiana</i> (Meliaceae)

• Main Authors: Hersa Milawati, Winda Sukmawati, Desi Harneti, Rani Maharani, Nurlelasari Nurlelasari, Ace Tatang Hidayat, Darwati Darwati, Unang Supratman, Yoshihito Shiono
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2020-05-01
• Series: Indonesian Journal of Chemistry
• Subjects: aglaia harmsiana; cytotoxic activity; aromadendrane-type sesquiterpenoid; mcf-7 cell lines
• Online Access: https://jurnal.ugm.ac.id/ijc/article/view/47808

Three aromadendrane-type sesquiterpenoids, spathulenol (1), 4β,10α-dihydroxyaromadendrane (2), and 4α,10α-dihydroxyaromadendrane (3) were isolated from the stem bark of Aglaia harmsiana (Meliaceae). Compound 3 was isolated for the first time from Aglaia genus. The chemical structures of isolated compounds were elucidated by various spectroscopic methods, including one and two-dimensional NMR, as well as mass spectroscopy analysis. These sesquiterpenoids 1-3 were evaluated for their cytotoxic activity against MCF-7 breast cancer cell lines. The IC50 value of compound 1-3 were 31.65 ± 0.1, 8.41 ± 0.04 and 2.80 ± 0.02 µM, respectively. Among the aromadendrane-type sesquiterpenoids, compounds 2 and 3, which do not have a double bond, showed higher activity than compound 1. Whereas, compound 3 showed the strongest activity indicate that α configuration of hydroxyl group increases the cytotoxic activity.