EVALUATION OF THE THERAPEUTIC EFFICACY OF HIGH-INTENSITY PULSED-PERIODIC LASER RADIATION (CLINICAL AND EXPERIMENTAL OBSERVATIONS)

• Main Authors: V. V. Sokolov, A. D. Kaprin, A. A. Pankratov, N. M. Lepekhin, Yu. S. Priseko, V. G. Filippov, M. V. Galyetov, A. V. Khrapov
• Format: Article
• Language: Russian
• Published: QUASAR, LLC 2016-09-01
• Series: Issledovaniâ i Praktika v Medicine
• Subjects: copper vapor laser; the time structure of radiation pulses; sarcoma s-37
• Online Access: https://www.rpmj.ru/rpmj/article/view/154

From the experience of clinical observations, we have shown a high therapeutic effectiveness of the medical laser KULON-MED in: cosmetics, non-cancer inflammatory diseases of the gastrointestinal tract and cancer (cancer of the stomach and colon) as at different wavelengths, and with different types of photosensitizers. In the area of anti-tumor photodynamic therapy (PDT), based on experimental studies, we have showed the high antitumor (sarcoma S‑37) effectiveness of the laser (with the inhibition of tumor growth of up to 100%) for repetitively pulsed irradiation mode, and for mode fractionation doses laser radiation. In addition, significant differences are shown in the effectiveness of anticancer PDT methods in the application of high-intensity lasers, continuous and pulsed caused fundamental properties of laser radiation characteristics – time structure of the radiation pulses. Thus, for the first time we have shown that the time of high-intensity laser pulses structure significantly affects therapeutic efficacy laser system, and hence on the mechanisms of interaction of laser radiation with biological tissue.