Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Abstract Osteoarthritis (OA) is a condition associated with severe inflammation, cartilage destruction and degeneration of joints. Rhein (Rh) is an effective anti-inflammatory drug with proven efficacy in in-vitro and in-vivo models. pH sensitive Rh and NH4HCO3 laden poly (lactic-co-glycolic acid (P...

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Bibliographic Details
Main Authors: Bo Hu, Feng Gao, Chunbao Li, Boqing Zhang, Mingyang An, Ming Lu, Yufeng Liu, Yujie Liu
Format: Article
Language:English
Published: SpringerOpen 2020-08-01
Series:AMB Express
Subjects:
PLGA
Nano-carriers
pH-sensitive
Anti-inflammatory
Drug delivery
Online Access:http://link.springer.com/article/10.1186/s13568-020-01095-3

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