Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes

Maham Hayat,1 Hassaan Zia,2 Salman Nusrat2 1Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Abstract: Chronic idiopathic c...

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Main Authors: Hayat M, Zia H, Nusrat S
Format: Article
Language:English
Published: Dove Medical Press 2019-02-01
Series:Patient Related Outcome Measures
Subjects:
Online Access:https://www.dovepress.com/lubiprostone-in-the-treatment-of-chronic-idiopathic-constipation-an-up-peer-reviewed-article-PROM
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spelling doaj-24792242f03743bfad74d5caab6d21942020-11-25T00:10:20ZengDove Medical PressPatient Related Outcome Measures1179-271X2019-02-01Volume 10434744040Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomesHayat MZia HNusrat SMaham Hayat,1 Hassaan Zia,2 Salman Nusrat2 1Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Abstract: Chronic idiopathic constipation, if inadequately treated, can be bothersome with a detrimental effect on patients’ quality of life (QOL). This may also result in frequent health care visits, increasing the burden of this ailment’s medical cost. Management strategies, focused on lifestyle changes, include increased exercise, a high-fiber diet, and toilet training. Pharmacologic options include fiber supplementation, laxatives, serotonergic agents, and prosecretory agents such as lubiprostone. In this review, we were able to conclude that lubiprostone, when used for chronic idiopathic constipation, has a significantly beneficial effect on both patients’ symptoms and their QOL. In multiple randomized controlled trials, it has been found to have increased the number of spontaneous bowel movements at different time endpoints. Corresponding improvements were also observed for abdominal bloating, discomfort, stool frequency, and straining symptoms among patients. Keywords: functional, gastrointestinal disorders, spontaneous bowel movements, secretory agents, abdominal pain, cost-effectiveness  https://www.dovepress.com/lubiprostone-in-the-treatment-of-chronic-idiopathic-constipation-an-up-peer-reviewed-article-PROMFunctionalgastrointestinal disordersspontaneous bowel movementssecretory agentsabdominal paincost effectiveness
collection DOAJ
language English
format Article
sources DOAJ
author Hayat M
Zia H
Nusrat S
spellingShingle Hayat M
Zia H
Nusrat S
Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
Patient Related Outcome Measures
Functional
gastrointestinal disorders
spontaneous bowel movements
secretory agents
abdominal pain
cost effectiveness
author_facet Hayat M
Zia H
Nusrat S
author_sort Hayat M
title Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
title_short Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
title_full Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
title_fullStr Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
title_full_unstemmed Lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
title_sort lubiprostone in the treatment of chronic idiopathic constipation: an update on health-related quality of life and patient-reported outcomes
publisher Dove Medical Press
series Patient Related Outcome Measures
issn 1179-271X
publishDate 2019-02-01
description Maham Hayat,1 Hassaan Zia,2 Salman Nusrat2 1Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Abstract: Chronic idiopathic constipation, if inadequately treated, can be bothersome with a detrimental effect on patients’ quality of life (QOL). This may also result in frequent health care visits, increasing the burden of this ailment’s medical cost. Management strategies, focused on lifestyle changes, include increased exercise, a high-fiber diet, and toilet training. Pharmacologic options include fiber supplementation, laxatives, serotonergic agents, and prosecretory agents such as lubiprostone. In this review, we were able to conclude that lubiprostone, when used for chronic idiopathic constipation, has a significantly beneficial effect on both patients’ symptoms and their QOL. In multiple randomized controlled trials, it has been found to have increased the number of spontaneous bowel movements at different time endpoints. Corresponding improvements were also observed for abdominal bloating, discomfort, stool frequency, and straining symptoms among patients. Keywords: functional, gastrointestinal disorders, spontaneous bowel movements, secretory agents, abdominal pain, cost-effectiveness  
topic Functional
gastrointestinal disorders
spontaneous bowel movements
secretory agents
abdominal pain
cost effectiveness
url https://www.dovepress.com/lubiprostone-in-the-treatment-of-chronic-idiopathic-constipation-an-up-peer-reviewed-article-PROM
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