Recombinant Sj16 protein with novel activity alleviates hepatic granulomatous inflammation and fibrosis induced by Schistosoma japonicum associated with M2 macrophages in a mouse model

Recombinant Sj16 protein with novel activity alleviates hepatic granulomatous inflammation and fibrosis induced by Schistosoma japonicum associated with M2 macrophages in a mouse model

Abstract Background Potent granulomatous inflammation responses induced by schistosome eggs and resultant fibrosis are the primary causes of morbidity in schistosomiasis. Recombinant Sj16 (rSj16), a 16-kDa protein of Schistosoma japonicum produced in Escherichia coli, has been demonstrated to have n...

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Bibliographic Details
Main Authors: Jia Shen, Lifu Wang, Mei Peng, Zhen Liu, Beibei Zhang, Tao Zhou, Xi Sun, Zhongdao Wu
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Parasites & Vectors
Subjects:
Schistosoma japonicum
rSj16
Granulomatous inflammation
Fibrosis
M2 macrophages
Online Access:http://link.springer.com/article/10.1186/s13071-019-3697-z

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