Assessment of Plasma Selenium-Binding Protein-1 Level in Geriatric Population

• Main Authors: Annisa F. Dewi, Lazuardhi Dwipa, Ronny Lesmana
• Format: Article
• Language: English
• Published: Universitas Padjadjaran 2017-08-01
• Series: Pharmacology and Clinical Pharmacy Research

Geriatric physiologically undergoes aging process that can cause decreasing cell function and increasing risk of degenerative diseases caused by the accumulation of reactive oxygen species (ROS) in the body. Selenium (Se) is an antioxidant, which is needed for maintaining the balance of ROS. The aim of this study was to observe the selenium-binding protein (SELENBP1) level in relation with the geriatric patients charcateristics including sex, age, body mass index (BMI), activity of daily living (ADL), instrumental activity of daily living (IADL), cognitive function, nutrition, depression, and insomnia status. The study used cross-sectional quantitative descriptive study design on 14 geriatric patients in Geriatric Outpatients Clinics, at a hospital in Bandung. The data was obtained by interviewing the patients and then blood samples were taken. The analysis of SELENBP1 was done using ELISA kit. The average level (SD) of SELENBP1 from all of the characteristics group was 2.68 (0.69) ng/ml. The highest SELENBP1 level was identified in female geriatric patients and followed by male and pre-obese groups. The lowest SELENBP1 level was identified in geriatric patients aged 70-79 years.