Therapies with CCL25 require controlled release via microparticles to avoid strong inflammatory reactions

Abstract Background Chemokine therapy with C–C motif chemokine ligand 25 (CCL25) is currently under investigation as a promising approach to treat articular cartilage degeneration. We developed a delayed release mechanism based on Poly (lactic-co-glycolic acid) (PLGA) microparticle encapsulation for...

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Bibliographic Details
Main Authors: J. Spinnen, K. Fröhlich, N. Sinner, M. Stolk, J. Ringe, L. Shopperly, M. Sittinger, T. Dehne, M. Seifert
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-021-00830-7