Pediatric Dosing and Body Size in Biotherapeutics

Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (AD...

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Bibliographic Details
Main Authors: Hartmut Derendorf, Rong Shi
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Pharmaceutics
Subjects:
Online Access:http://www.mdpi.com/1999-4923/2/4/389/