Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production

Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production

Abstract Cigarette smoke (CS) is a major risk factor for the development of lung cancer and chronic obstructive pulmonary disease (COPD). Epithelial-mesenchymal transition (EMT) commonly coexists in lung cancer and COPD. CS triggers many factors including matrix metalloproteinases (MMPs) production,...

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Main Authors: Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie, Yicheng Xie
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Respiratory Research
Online Access:http://link.springer.com/article/10.1186/s12931-020-01426-9

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