Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardi...

Full description

Bibliographic Details
Main Authors:	Yapeng Lu, Rui Liu, Luting Zha, Shan Yuan, Lang Tian, Jia Chen, Lihua Huang, Zuocheng Yang
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Disease Markers
Online Access:	http://dx.doi.org/10.1155/2018/1064380

id	doaj-2452190dacfe4aa0b2bdb3a095ff76fc
record_format	Article
spelling	doaj-2452190dacfe4aa0b2bdb3a095ff76fc2020-11-24T22:41:50ZengHindawi LimitedDisease Markers0278-02401875-86302018-01-01201810.1155/2018/10643801064380Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese ChildrenYapeng Lu0Rui Liu1Luting Zha2Shan Yuan3Lang Tian4Jia Chen5Lihua Huang6Zuocheng Yang7Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaCentral Laboratory, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, ChinaKawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.http://dx.doi.org/10.1155/2018/1064380
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yapeng Lu Rui Liu Luting Zha Shan Yuan Lang Tian Jia Chen Lihua Huang Zuocheng Yang
spellingShingle	Yapeng Lu Rui Liu Luting Zha Shan Yuan Lang Tian Jia Chen Lihua Huang Zuocheng Yang Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children Disease Markers
author_facet	Yapeng Lu Rui Liu Luting Zha Shan Yuan Lang Tian Jia Chen Lihua Huang Zuocheng Yang
author_sort	Yapeng Lu
title	Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_short	Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_full	Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_fullStr	Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_full_unstemmed	Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_sort	association of thrombomodulin gene c1418t polymorphism with susceptibility to kawasaki disease in chinese children
publisher	Hindawi Limited
series	Disease Markers
issn	0278-0240 1875-8630
publishDate	2018-01-01
description	Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.
url	http://dx.doi.org/10.1155/2018/1064380
work_keys_str_mv	AT yapenglu associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT ruiliu associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT lutingzha associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT shanyuan associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT langtian associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT jiachen associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT lihuahuang associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren AT zuochengyang associationofthrombomodulingenec1418tpolymorphismwithsusceptibilitytokawasakidiseaseinchinesechildren
_version_	1725700678465093632

Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

Similar Items