Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model

Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model

The immune system, and in particular, cytotoxic CD8+ T cells (CTLs), plays a vital part in the prevention and elimination of tumors. In many patients, however, CTL-mediated tumor killing ultimately fails in the clearance of cancer cells resulting in disease progression, in large part due to the prog...

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Bibliographic Details
Main Authors: Jennifer L. Hope, Panagiota I. Spantidea, Caoimhe H. Kiernan, Christopher J. Stairiker, Laurine C. Rijsbergen, Marjan van Meurs, Inge Brouwers-Haspels, Yvonne M. Mueller, Delia J. Nelson, Linda M. Bradley, Joachim G. J. V. Aerts, Peter D. Katsikis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
cancer
CD8+ T cells
T cell exhaustion
tumors
peripheral lymphoid organs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03074/full

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