Unfolded Protein Response: A Regulator of the Endothelial Barrier

Unfolded Protein Response: A Regulator of the Endothelial Barrier

Recent evidence suggest that the endothelial barrier function is enhanced by the mild activation of the unfolded protein response (UPR), which aims to suppress abnormal increases of endoplasmic reticulum stress. Heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists exert...

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Main Author: Nektarios Barabutis
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Endocrine and Metabolic Science
Subjects:
Inflammation
Acute Lung Injury
Acute Respiratory Distress Syndrome
Sepsis
P53
Online Access:http://www.sciencedirect.com/science/article/pii/S2666396121000157
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spelling doaj-24430b5f11a54aef91a9d1c76816cde62021-05-28T05:04:28ZengElsevierEndocrine and Metabolic Science2666-39612021-06-013100092Unfolded Protein Response: A Regulator of the Endothelial BarrierNektarios Barabutis0Correspondence author: School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 1800 Bienville Drive, Monroe, Louisiana 71201, United States of America.; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana 71201, USARecent evidence suggest that the endothelial barrier function is enhanced by the mild activation of the unfolded protein response (UPR), which aims to suppress abnormal increases of endoplasmic reticulum stress. Heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists exert the capacity to activate this multifaceted cellular mechanism (UPR). Thus, investigations on the signalling network involved in those events, may deliver exciting opportunities in diseases related to endothelial barrier dysfunction. The diverse spectrum of those pathologies include sepsis and Acute Respiratory Distress Syndrome (ARDS).http://www.sciencedirect.com/science/article/pii/S2666396121000157InflammationAcute Lung InjuryAcute Respiratory Distress SyndromeSepsisP53
collection DOAJ
language English
format Article
sources DOAJ
author Nektarios Barabutis
spellingShingle Nektarios Barabutis
Unfolded Protein Response: A Regulator of the Endothelial Barrier
Endocrine and Metabolic Science
Inflammation
Acute Lung Injury
Acute Respiratory Distress Syndrome
Sepsis
P53
author_facet Nektarios Barabutis
author_sort Nektarios Barabutis
title Unfolded Protein Response: A Regulator of the Endothelial Barrier
title_short Unfolded Protein Response: A Regulator of the Endothelial Barrier
title_full Unfolded Protein Response: A Regulator of the Endothelial Barrier
title_fullStr Unfolded Protein Response: A Regulator of the Endothelial Barrier
title_full_unstemmed Unfolded Protein Response: A Regulator of the Endothelial Barrier
title_sort unfolded protein response: a regulator of the endothelial barrier
publisher Elsevier
series Endocrine and Metabolic Science
issn 2666-3961
publishDate 2021-06-01
description Recent evidence suggest that the endothelial barrier function is enhanced by the mild activation of the unfolded protein response (UPR), which aims to suppress abnormal increases of endoplasmic reticulum stress. Heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists exert the capacity to activate this multifaceted cellular mechanism (UPR). Thus, investigations on the signalling network involved in those events, may deliver exciting opportunities in diseases related to endothelial barrier dysfunction. The diverse spectrum of those pathologies include sepsis and Acute Respiratory Distress Syndrome (ARDS).
topic Inflammation
Acute Lung Injury
Acute Respiratory Distress Syndrome
Sepsis
P53
url http://www.sciencedirect.com/science/article/pii/S2666396121000157
work_keys_str_mv AT nektariosbarabutis unfoldedproteinresponsearegulatoroftheendothelialbarrier
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