Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells

Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells

Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene (ESR1) regulation after hormonal stimulation, how it is regulated in hormone-free conditi...

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Bibliographic Details
Main Authors: Gaetano Verde, Lara I. De Llobet, Roni H.G. Wright, Javier Quilez, Sandra Peiró, François Le Dily, Miguel Beato
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
progesterone receptor
estrogen receptor
gene expression
DNA methylation
breast cancer
endocrine therapy
Online Access:http://www.mdpi.com/2072-6694/10/10/371

Internet

http://www.mdpi.com/2072-6694/10/10/371

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