Hyperconserved Elements in Human 5′UTRs Shape Essential Post-transcriptional Regulatory Networks

Hyperconserved Elements in Human 5′UTRs Shape Essential Post-transcriptional Regulatory Networks

Post-transcriptional regulation (PTR) of gene expression is a powerful determinant of cellular phenotypes. The 5′ and 3′ untranslated regions of the mRNA (UTRs) mediate this role through sequence and secondary structure elements bound by RNA-binding proteins (RBPs) and non-coding RNAs. While functio...

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Bibliographic Details
Main Authors: Paola Zuccotti, Daniele Peroni, Valentina Potrich, Alessandro Quattrone, Erik Dassi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
post-transcriptional regulation
5cpsdummy′UTR
phylogenetic conservation
regulatory networks
RNA-binding proteins
homeobox
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00220/full

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