Heteromeric TRP Channels in Lung Inflammation

Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca<sup>2+</sup> influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial p...

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Main Authors:	Meryam Zergane, Wolfgang M. Kuebler, Laura Michalick
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Cells
Subjects:	heteromeric TRP assemblies pulmonary inflammation endothelial permeability TRPC3/6 TRPV1/4 TRPC1/4
Online Access:	https://www.mdpi.com/2073-4409/10/7/1654

id	doaj-242a8eb8aa744736bf9b553283eab1ea
record_format	Article
spelling	doaj-242a8eb8aa744736bf9b553283eab1ea2021-07-23T13:34:46ZengMDPI AGCells2073-44092021-07-01101654165410.3390/cells10071654Heteromeric TRP Channels in Lung InflammationMeryam Zergane0Wolfgang M. Kuebler1Laura Michalick2Institute of Physiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, GermanyInstitute of Physiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, GermanyInstitute of Physiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, GermanyActivation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca<sup>2+</sup> influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells and formation of pulmonary edema. Interestingly, TRP channel subunits can build heterotetramers, whereas heteromeric TRPC1/4, TRPC3/6 and TRPV1/4 are expressed in the lung endothelium and could be targeted as a protective strategy to reduce endothelial permeability in pulmonary inflammation. An update on TRP heteromers and their role in lung inflammation will be provided with this review.https://www.mdpi.com/2073-4409/10/7/1654heteromeric TRP assembliespulmonary inflammationendothelial permeabilityTRPC3/6TRPV1/4TRPC1/4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Meryam Zergane Wolfgang M. Kuebler Laura Michalick
spellingShingle	Meryam Zergane Wolfgang M. Kuebler Laura Michalick Heteromeric TRP Channels in Lung Inflammation Cells heteromeric TRP assemblies pulmonary inflammation endothelial permeability TRPC3/6 TRPV1/4 TRPC1/4
author_facet	Meryam Zergane Wolfgang M. Kuebler Laura Michalick
author_sort	Meryam Zergane
title	Heteromeric TRP Channels in Lung Inflammation
title_short	Heteromeric TRP Channels in Lung Inflammation
title_full	Heteromeric TRP Channels in Lung Inflammation
title_fullStr	Heteromeric TRP Channels in Lung Inflammation
title_full_unstemmed	Heteromeric TRP Channels in Lung Inflammation
title_sort	heteromeric trp channels in lung inflammation
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2021-07-01
description	Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca<sup>2+</sup> influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells and formation of pulmonary edema. Interestingly, TRP channel subunits can build heterotetramers, whereas heteromeric TRPC1/4, TRPC3/6 and TRPV1/4 are expressed in the lung endothelium and could be targeted as a protective strategy to reduce endothelial permeability in pulmonary inflammation. An update on TRP heteromers and their role in lung inflammation will be provided with this review.
topic	heteromeric TRP assemblies pulmonary inflammation endothelial permeability TRPC3/6 TRPV1/4 TRPC1/4
url	https://www.mdpi.com/2073-4409/10/7/1654
work_keys_str_mv	AT meryamzergane heteromerictrpchannelsinlunginflammation AT wolfgangmkuebler heteromerictrpchannelsinlunginflammation AT lauramichalick heteromerictrpchannelsinlunginflammation
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Heteromeric TRP Channels in Lung Inflammation

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