Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults

<p>Abstract</p> <p>Background</p> <p>Accumulating data suggest a novel role for bile acids (BAs) in modulating metabolic homeostasis. BA treatment has been shown to improve glucose tolerance and to increase energy expenditure in mice. Here, we investigated the relations...

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Main Authors: Laville Martine, Guyomarc'h-Delasalle Béatrice, Disse Emmanuel, Pouteau Etienne, Zaïr Yassine, Chetiveaux Maud, Cariou Bertrand, Krempf Michel
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Nutrition & Metabolism
Subjects:
FXR
Online Access:http://www.nutritionandmetabolism.com/content/8/1/48
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spelling doaj-24242514c80c4ec3914b136f510657552020-11-25T01:58:22ZengBMCNutrition & Metabolism1743-70752011-07-01814810.1186/1743-7075-8-48Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adultsLaville MartineGuyomarc'h-Delasalle BéatriceDisse EmmanuelPouteau EtienneZaïr YassineChetiveaux MaudCariou BertrandKrempf Michel<p>Abstract</p> <p>Background</p> <p>Accumulating data suggest a novel role for bile acids (BAs) in modulating metabolic homeostasis. BA treatment has been shown to improve glucose tolerance and to increase energy expenditure in mice. Here, we investigated the relationship between fasting plasma BAs concentrations and metabolic parameters in humans.</p> <p>Findings</p> <p>Fasting plasma glucose, insulin and lipid profile were measured in 14 healthy volunteers, 20 patients with type 2 diabetes (T2D), and 22 non-diabetic abdominally obese subjects. Insulin sensitivity was also assessed by the determination of the glucose infusion rate (GIR) during a hyperinsulinemic-euglycemic clamp in a subgroup of patients (9 healthy and 16 T2D subjects). Energy expenditure was measured by indirect calorimetry. Plasma cholic acid (CA), chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) concentrations were analyzed by gas chromatograph-mass spectrometry. In univariable analysis, a positive association was found between HOMA-IR and plasma CDCA (β = 0.09, p = 0.001), CA (β = 0.03, p = 0.09) and DCA concentrations (β = 0.07, p < 0.0001). Spearman analysis retrieved an inverse relationship between plasma CDCA (r = -0.44, p = 0.03), CA (r = -0.65, p = 0.001) and the GIR. HOMA-IR remained positively associated with CDCA (β = 0.11, p = 0.01), CA (β = 0.04, p = 0.01) and DCA (β = 0.06, p = 0.007) in multivariable analysis, after adjustment for age, gender, BMI, HbA1C and plasma lipid parameters. In contrast, HbA1c, energy expenditure and plasma lipid concentrations were not correlated with plasma BAs levels in multivariable analysis.</p> <p>Conclusions</p> <p>Both plasma CDCA, CA and DCA concentrations were negatively associated with insulin sensitivity in a wide range of subjects.</p> http://www.nutritionandmetabolism.com/content/8/1/48bile acidsinsulin resistancetype 2 diabetesFXRTGR5energy expenditurehyperinsulinemic-euglycemic clamp
collection DOAJ
language English
format Article
sources DOAJ
author Laville Martine
Guyomarc'h-Delasalle Béatrice
Disse Emmanuel
Pouteau Etienne
Zaïr Yassine
Chetiveaux Maud
Cariou Bertrand
Krempf Michel
spellingShingle Laville Martine
Guyomarc'h-Delasalle Béatrice
Disse Emmanuel
Pouteau Etienne
Zaïr Yassine
Chetiveaux Maud
Cariou Bertrand
Krempf Michel
Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
Nutrition & Metabolism
bile acids
insulin resistance
type 2 diabetes
FXR
TGR5
energy expenditure
hyperinsulinemic-euglycemic clamp
author_facet Laville Martine
Guyomarc'h-Delasalle Béatrice
Disse Emmanuel
Pouteau Etienne
Zaïr Yassine
Chetiveaux Maud
Cariou Bertrand
Krempf Michel
author_sort Laville Martine
title Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
title_short Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
title_full Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
title_fullStr Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
title_full_unstemmed Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
title_sort fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
publisher BMC
series Nutrition & Metabolism
issn 1743-7075
publishDate 2011-07-01
description <p>Abstract</p> <p>Background</p> <p>Accumulating data suggest a novel role for bile acids (BAs) in modulating metabolic homeostasis. BA treatment has been shown to improve glucose tolerance and to increase energy expenditure in mice. Here, we investigated the relationship between fasting plasma BAs concentrations and metabolic parameters in humans.</p> <p>Findings</p> <p>Fasting plasma glucose, insulin and lipid profile were measured in 14 healthy volunteers, 20 patients with type 2 diabetes (T2D), and 22 non-diabetic abdominally obese subjects. Insulin sensitivity was also assessed by the determination of the glucose infusion rate (GIR) during a hyperinsulinemic-euglycemic clamp in a subgroup of patients (9 healthy and 16 T2D subjects). Energy expenditure was measured by indirect calorimetry. Plasma cholic acid (CA), chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) concentrations were analyzed by gas chromatograph-mass spectrometry. In univariable analysis, a positive association was found between HOMA-IR and plasma CDCA (β = 0.09, p = 0.001), CA (β = 0.03, p = 0.09) and DCA concentrations (β = 0.07, p < 0.0001). Spearman analysis retrieved an inverse relationship between plasma CDCA (r = -0.44, p = 0.03), CA (r = -0.65, p = 0.001) and the GIR. HOMA-IR remained positively associated with CDCA (β = 0.11, p = 0.01), CA (β = 0.04, p = 0.01) and DCA (β = 0.06, p = 0.007) in multivariable analysis, after adjustment for age, gender, BMI, HbA1C and plasma lipid parameters. In contrast, HbA1c, energy expenditure and plasma lipid concentrations were not correlated with plasma BAs levels in multivariable analysis.</p> <p>Conclusions</p> <p>Both plasma CDCA, CA and DCA concentrations were negatively associated with insulin sensitivity in a wide range of subjects.</p>
topic bile acids
insulin resistance
type 2 diabetes
FXR
TGR5
energy expenditure
hyperinsulinemic-euglycemic clamp
url http://www.nutritionandmetabolism.com/content/8/1/48
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