Optimization and validation of bioanalytical SPE – HPLC method for the simultaneous determination of carbamazepine and its main metabolite, carbamazepine-10, 11-epoxide, in plasma

Optimization and validation of bioanalytical SPE – HPLC method for the simultaneous determination of carbamazepine and its main metabolite, carbamazepine-10, 11-epoxide, in plasma

Carbamazepine is widely used as an antiepileptic drug in the treatment of partial and generalized tonic-clonic seizures. Carbamazepine 10,11-epoxide is the most important metabolite of carbamazepine, because it is a pharmacologically active compound with anticonvulsant properties. According to that,...

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Bibliographic Details
Main Authors: Jasmina Tonic – Ribarska, Zoran Sterjev, Emilija Cvetkovska, Igor Kuzmanovski, Gordana Kiteva, Ljubica Suturkova, Suzana Trajkovic - Jolevska
Format: Article
Language:English
Published: University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association 2012-03-01
Series:Makedonsko Farmacevtski Bilten
Online Access:http://bulletin.mfd.org.mk/volumes/Volume%2057/57_006.pdf

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