Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer

Summary: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to overcome treatment resistance. Whereas a...

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Bibliographic Details
Main Authors: Rachel M. Guerra, Gregory H. Bird, Edward P. Harvey, Neekesh V. Dharia, Kyle J. Korshavn, Michelle S. Prew, Kimberly Stegmaier, Loren D. Walensky
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314086

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