Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth. However, the consequences of FcRn down-regulation in the anti-tumor immune respo...

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Bibliographic Details
Main Authors: Diana Cadena Castaneda, Christine Dhommée, Thomas Baranek, Emilie Dalloneau, Laurie Lajoie, Alexandre Valayer, Christophe Arnoult, Marie-Véronique Demattéi, Delphine Fouquenet, Christelle Parent, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
FcRn
anti-tumor immunity
NK cells
IFN-γ
CD107a
fcgrt knock-out
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02259/full

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