Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-<i>miR-122</i> Feedback Loop in Liver Fibrosis and Cancer Progression

Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-<i>miR-122</i> Feedback Loop in Liver Fibrosis and Cancer Progression

Hepatitis C virus (HCV) infection compromises the natural defense mechanisms of the liver leading to a progressive end stage disease such as cirrhosis and hepatocellular carcinoma (HCC). The hepatic stress response generated due to viral replication in the endoplasmic reticulum (ER) undergoes a step...

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Bibliographic Details
Main Authors: Yucel Aydin, Ramazan Kurt, Kyoungsub Song, Dong Lin, Hanadi Osman, Brady Youngquist, John W. Scott, Nathan J. Shores, Paul Thevenot, Ari Cohen, Srikanta Dash
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
hepatitis C virus (HCV)
cirrhosis
hepatocellular carcinoma (HCC)
endoplasmic reticulum (ER) stress
oxidative stress (OS)
unfolded protein response (UPR)
<i>microRNA-122</i> (<i>miR-122</i>)
nuclear factor erythroid 2-related factor 2 (NRF2)
signal transducer and activator of transcription 3 (STAT3)
hepatocyte nuclear factor 4 alpha (HNF4A)
Online Access:https://www.mdpi.com/2072-6694/11/10/1407

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https://www.mdpi.com/2072-6694/11/10/1407

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