AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.

AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.

The RUN and FYVE domain proteins rabip4 and rabip4' are encoded by RUFY1 and differ in a 108 amino acid N-terminal extension in rabip4'. Their identical C terminus binds rab5 and rab4, but the function of rabip4s is incompletely understood. We here found that silencing RUFY1 gene products...

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Bibliographic Details
Main Authors: Viorica Ivan, Emma Martinez-Sanchez, Livia E Sima, Viola Oorschot, Judith Klumperman, Stefana M Petrescu, Peter van der Sluijs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3483219?pdf=render

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