Heterologous expression and antitumor activity analysis of syringolin from Pseudomonas syringae pv. syringae B728a

Heterologous expression and antitumor activity analysis of syringolin from Pseudomonas syringae pv. syringae B728a

Abstract Background Syringolin, synthesized by a mixed non-ribosomal peptide synthetase/polyketide synthetase in Pseudomonas syringae pv. syringae (Pss) B728a, is a novel eukaryotic proteasome inhibitor. Meanwhile, directly modifying large fragments in the PKS/NRPS gene cluster through traditional D...

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Bibliographic Details
Main Authors: Fan Huang, Jianli Tang, Lian He, Xuezhi Ding, Shaoya Huang, Youming Zhang, Yunjun Sun, Liqiu Xia
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Microbial Cell Factories
Subjects:
Antitumor
Heterologous expression
Red/ET recombineering
Syringolin
Streptomyces
Online Access:http://link.springer.com/article/10.1186/s12934-018-0859-1

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