High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and Impair in vitro Trophoblastic Cell Migration

High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and Impair in vitro Trophoblastic Cell Migration

Placentas from preeclamptic women display augmented tumor necrosis factor-alpha (TNF-α) levels with reduced expression of aquaporin 3 (AQP3). However, whether TNF-α modulates AQP3 expression remains to be elucidated. We hypothesize that elevated levels of TNF-α reduce AQP3 expression and negatively...

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Bibliographic Details
Main Authors: Rinaldo Rodrigues dos Passos Junior, Raiany Alves de Freitas, Julieta Reppetti, Yollyseth Medina, Vanessa Dela Justina, Camila Werle Bach, Gisele Facholi Bomfim, Victor Vitorino Lima, Alicia E. Damiano, Fernanda R. Giachini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
placenta
hypertensive pregnancy
preeclampsia
trophoblastic cell
migration
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.696495/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.696495/full

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