Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Objective: Chronic hypoxia causes pulmonary vasoconstriction leading to pulmonary hypertension and right ventricular hypertrophy. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis; its level increases in hypoxia (HX) concomitantly with reduced activity of d...

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Bibliographic Details
Main Authors: Juliane Hannemann, Antonia Glatzel, Jonas Hillig, Julia Zummack, Udo Schumacher, Nicole Lüneburg, Lars Harbaum, Rainer Böger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
hypoxia
nitric oxide
hypoxic vasoconstriction
endothelium
ADMA
DDAH
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.597559/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.597559/full

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